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DPP4 might be involved in adipose tissue lipolysis

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Important safety considerations include boxed warnings for thyroid C-cell tumors (based on animal studies), and cautions regarding pancreatitis and gallbladder disease

The most common exclusion criteria included major depressive disorder, uncontrolled hypertension, malignant neoplasms and liver disease, with the latter for tirzepatide only

The authors of this study said this may be attributed to improved cardiometabolic parameters, which lead to fewer sudden health problems and subsequent emergency room visits

[DOI] [PubMed] [Google Scholar] 869.Henriksen D.B., Alexandersen P., Bjarnason N.H., Vilsboll T., Hartmann B., Henriksen E.E