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However, Zepbounds sleep apnea approval may open new coverage pathways, depending on insurer policies

[DOI] [PubMed] [Google Scholar] 83.Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, et al

Practical Application Consistent sleep schedule: Same bedtime/wake time, including weekends 7-9 hours nightly: Inadequate sleep duration increases DPP-4 Sleep quality: Deep, uninterrupted sleep matters more than just duration Light exposure: Bright light morning, dim light evening supports circadian rhythm Eat larger meals earlier in the day when DPP-4 activity is naturally lower Avoid late-night eating when DPP-4 activity peaks Morning protein intake may benefit from lower DPP-4 activity Strategy 6: Managing Inflammation and Metabolic Stress The Science: Chronic low-grade inflammation and metabolic stress significantly upregulate DPP-4 expression