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Research demonstrates that GLP-1 receptor activation improves beta-cell function, reduces hepatic fat accumulation, and lowers inflammatory markers independent of substantial weight loss

A research review of 28 trials and 23,000 patients showed that tirzepatide produces slightly more weight loss than semaglutide compared to a placebo

van der Schoot A, et al

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In both clinical and preclinical models, upon removal of GLP-1R agonists, body weight rebounds rapidly to its initial level or an even higher level

90 Taken together, these findings indicate that autophagy is involved in the occurrence and development of UC and that the inhibition of autophagy could be a therapeutic strategy for treating UC by alleviating intestinal inflammation