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While the TTE approach yielded consistent hazard ratios between censored and non-censored analyses, the estimated difference between treatment arms using the change-from-baseline approach was lower without censoring than with censoring, suggesting a potential masking of prasinezumab treatment effects by symptomatic therapy

Additionally, the body may need time to adjust to the medication, resulting in temporary nausea as it acclimates to the treatment regimen

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Scientists report that as the mice lost weight, some skeletal muscles did decrease, while other muscles stayed the same

SURMOUNT trials demonstrated ~22% body weight reduction vs ~15% for semaglutide at highest doses