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doi:10.1038/nrendo.2011.183 31

GLP-1 microdosing is an emerging practice where individuals take sub-therapeutic doses of GLP-1 medications typically 0.05 to 0.25mg of semaglutide weekly versus the standard 0.25 to 2.4mg to minimize side effects while achieving gradual weight loss and metabolic benefits

Among non-human primates (NHPs), the highest GLP-1 immunoreactivity is present in the hypothalamus, the area postrema, the NTS, and the dorsal vagal nucleus ( Figure 2 Dysfunction of GLP-1 and Diseases GLP-1 and AD AD is the most common neurodegenerative disease with an incurable cognitive impairment, but recently hope is proposed due to the development of Biogens monoclonal antibody drug aducanumab (ADU) in the USA

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The secondary antibodies were anti-mouse (GE Healthcare, Chicago, IL, USA, EUA) and anti-rabbit (Bio-Rad, Des Plaines, IL, USA)