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Patient Cost Sharing Library The Complex Web Behind Low Persistence Low persistence in GLP-1 therapy is rarely the result of a single factor

Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors

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And the cross-sectional design lacks the longitudinal dose-escalation data needed to understand how genetics interacts with the titration schedules most patients actually follow

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Results At 1 year, patients achieved significant weight loss with a median total weight loss (%TWL) of 25.5% and a median excess weight loss (%EWL) of 66.3% compared to 16.6% and 40.8%, respectively, at treatment initiation with BMI reduction of 3.7 kg/m2