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Doctors have historically done a bad job counseling patients about weight loss, and many people arent comfortable talking to their primary care doctor about it, Ard said

29 Given the above admittedly inconsistent evidence, contraindications for the use of GLP-1 RAs are: a history of pancreatitis pancreatic cancer multiple endocrine neoplasia type 2 medullary thyroid carcinoma creatinine clearance less than 30 mL/min for exenatide and semaglutide creatinine clearance less than 15 mL/min for dulaglutide