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Pharmacokinetics, safety and tolerability of oral semaglutide in subjects with renal impairment
Studies support the role of GLP-1 in paracrine regulationincrease in pancreatic insulin secretion and decrease in glucagon secretion leading to non-hepatic skeletal muscle glucose disposal (uptake) in the initial prandial state and increased hepatic glucose disposal in the postprandial state [32]
Ann Surg 246: 780785, 2007
Semaglutide also improves the glomerular filtration rate, supporting overall renal health
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