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In animal studies, GLP-1RA exposure was associated with reduced fetal growth, delayed skeletal ossification, and reductions in maternal weight gain and food consumption (109)

GLP-1 analogues like semaglutide and liraglutide, which were primarily used for glycemic control, are now being widely prescribed, particularly for the management of chronic weight management

Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions

One large electronic database study showed there was a significantly increased risk of diabetic macular edema following GLP-1RA initiation compared to sodium-glucose cotransporter 2 inhibitors (SGLT2i)

Sabrina Wong and Gia Han Le declare no competing interests

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