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These effects are attributed to restoration of neuronal insulin signaling, inhibition of GSK3, reducing NF-B/NLRP3-induced inflammation, and normalization of mitochondrial function and mitophagy

Another paper by the same group showed that incubation of HCAECs with exendin-4 resulted in a dose-dependent up-regulation of DNA synthesis which was associated with enhanced eNOS and Akt expression [106]

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The team focused on GLP-1 receptor agonists because the GLP-1 receptor is highly expressed in lung cells

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care delivery systems from 2014 to 2022, American Indian/Alaska Native, Asian, Black, Hawaiian or Pacific Islander, and Hispanic individuals were less likely to be prescribed a GLP-1 than White individuals [230]