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The practical safety considerations are all related to the side effects of the medication rather than the training itself: Nausea: Most common during dose titration

Blood sugar fluctuations during the night Tirzepatide improves insulin sensitivity and alters glucose metabolism

Both semaglutide and tirzepatide can cause gastrointestinal side effects: nausea, vomiting, diarrhoea, and stomach discomfort

In addition, GHSR agonists can provide relief to diabetic individuals experiencing nausea and vomiting as a result of gastroparesis [161,162,163,164]