long term glp-1 Long-Term Safety: GI Risks After 3 Years Long-term Success of GLP-1s Hinges
Description
12 These immunomodulatory effects are reflected by reductions of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), serum amyloid A (SAA), and interleukin-6 (IL-6) and other inflammatory cytokines and markers of oxidative stress
Orforglipron also is more likely to increase heart rate (by about 4 beats per minute)
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The mice were then treated with berberine (BBR) (100 mg/kg/day) for 8 weeks to test the impact on GLP-1 expression
Study link This isnt about trends, its about evidence
They may also slow the progression of diabetes-related nephropathy, making them valuable in comprehensive diabetes management (10)
