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Os ensaios clnicos mostram um perfil de segurana consistente, especialmente em pacientes com diabetes tipo 2 e alto risco cardiovascular

Consistent with this, GLP-1R agonism decreases a variety of reward behaviors in rodents, including the motivation to lever press for food reward in an operant conditioning test [746], alcohol intake [747,748], alcohol seeking behavior [747], amphetamine-induced conditioned place preference (Amp-CPP) [748], and hedonic feeding [748]

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Kidney transplant recipients taking the medications also had a 31 percent reduced risk of dying within five years of their starting on the medication, compared to those who did not take the drugs

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