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The magnitude of this risk parallels the severity of NAFLD (especially the liver fibrosis stage) [114]

These products typically contain dietary ingredients like berberine, green tea extract, curcumin or ashwagandha, which have long been found in other supplements before the rising popularity of GLP-1 agonists

Always consult your prescribing provider before starting, adjusting, or stopping this therapy

[DOI] [PubMed] [Google Scholar] Syme CA, Zhang L, Bisello A

If plateau persists despite dose escalation, your healthcare provider may recommend switching to tirzepatide (which acts on two receptor types rather than one) or adding a complementary agent through PlexusDx's GLP-Squared protocol

This characteristic may improve renal function by increasing renal blood flow, urine flow rate, preventing elevated plasma creatinine, reducing tubular necrosis, increasing renal interstitial fluid and glomerular filtration rate, and cytoprotective and anti-inflammatory effects [12,13], and may improve glomerular hyperosmosis in patients with T2DM in some cases [14]