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As with other incretin-based therapies, the most commonly reported adverse effects in the retatrutide phase 2 trial were gastrointestinal in nature

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While this is most common in people who use insulin, injection-technique guidance recommends rotating injection spots

More recently, a multisociety clinical practice guideline superseded this and offered a more comprehensive framework for shared decision-making between clinician and patient for the perioperative period.34 This guideline outlines features which are associated with increased risk: patients in the escalation phase of treatment, those on higher doses, those receiving weekly rather than daily GLP-1RA, patients with current GI symptoms and those with another reason for delayed gastric emptying (diabetes, Parkinsons disease, other medications known to slow emptying)