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GLP-1-based therapies have also been linked to more severe, albeit rare, gastrointestinal side effects, including intestinal obstruction and symptomatic gastroparesis [121]

Even insured users report difficulty affording them, over half of whom find them somewhat or very hard to pay for

This has led to ethical concerns, as the increased demand helped create a shortage of these drugs around the world in recent months

DeVries, J

Zhao T, Chen H, Cheng C, Zhang J, Yan Z, Kuang J, Kong F, Li C, Lu Q

In 2026, results from a larger and longer phase 3 trial supported these findings