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The physiological effects of GIP, GLP-1, and GLP-1RAs on bone metabolism have not yet been determined, and studies are needed to examine the effects of gut hormone on human osteoblast differentiation and osteoclast activity, including their potential interactions with Wnt and NF-kB signaling

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Mounjaro is the first and only drug in its class that activates two gut hormones that regulate blood sugar in people with type 2 diabetes: GLP-1 and GIP

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However, many patients begin to see noticeable weight loss within a few weeks of starting treatment

Another study of three PWS patients on GLP-1 agonists showed sustained improvements in eating behavior and weight stabilization over 12 months, with no serious adverse events