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Figure 1 Figure 2 Accordingly, DPP-4 can be viewed as a multi-functional protein with a spectrum of actions which go beyond its role as a proteolytic enzyme

One of the major drawbacks to the use of the native peptide in the clinic is its rapid degradation in serum due to the presence of a dipeptidyl peptidase-IV (DPP-IV, also known as CD26) recognition site in the N-terminus (Hansen et al., 1999)

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Individuals with type 2 diabetes who have not achieved adequate blood sugar control with other oral medications or who require additional treatment beyond oral medications may be candidates for GLP-1 therapy