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Mitchell JL, Lyons HS, Walker JK, Yiangou A, Grech O, Alimajstorovic Z, Greig NH, Li Y, Tsermoulas G, Brock K, Mollan SP, Sinclair AJ

Hayes MR, De Jonghe BC, Kanoski SE

Wegovy (semaglutide) is a GLP-1 receptor agonist specifically licensed by the MHRA for weight management in adults with obesity, recommended by NICE within specialist NHS services

Dose increases beyond 12mg dont occur in current protocols because 12mg represents maximum studied dose, not because higher doses are needed

In conclusion, tirzepatide increased blood pressure and sympathetic activity in hypertensive rats without cardiac protection, highlighting context-dependent cardiovascular actions
