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This is where the majority of reported adverse outcomes originate

This prescription medication is primarily used to control Type 2 diabetes by slowing the rate at which the liver releases sugar into the blood

Modulation of eating behavior and more sustained insulin action combined with reduced glucagon secretion leads to lower blood glucose levels and the creation of an energy deficit, forcing cells to seek alternative routes for energy production

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That can include cognitive behavioral therapy, contingency management, peer or recovery support, sleep and nutrition stabilization, and treatment for depression, anxiety, or trauma when present

The hypothalamus (particularly the melanocortin circuit) is a classic model that is susceptible to upregulation of developmental compensatory pathways that mask food intake and body weight phenotypes (Wu & Palmiter, 2011