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Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy

Some people may have mild side effects while taking the drug

doi: 10.1172/JCI186652 47 GuarnottaVBiancoMJVigneriEPantoFLo SassoBCiaccioMet al

Adjusting your fiber intake alongside GLP-1 support requires a strategic approach

At present, there is no evidence to support the use of GLP-1RAs as primary therapy or as adjunctive treatment alongside other advanced therapies specifically for IBD or for IBD patients with metabolic risk factors

This dual-pathway activity is one reason tirzepatide is often discussed as a stronger option for weight management