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Sodium-glucose Cotransporter Protein-2 (SGLT-2) Inhibitors and Glucagon-like Peptide-1 (GLP-1) Receptor Agonists for Type 2 Diabetes: Systematic Review and Network Meta-Analysis of Randomised Controlled Trials

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Patients should also seek immediate medical care if they experience severe, persistent abdominal pain (possibly radiating to the back) with or without vomiting, which could indicate pancreatitis

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Constipation-predominant IBS was linked to lower mucosal expression of GLP-1R and blood GLP-1 concentrations (28)