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That cross-substance signal points to a shared biology underlying addiction, and it opens the door to a fundamentally different approach: not treating one addiction at a time, but targeting that common biologic signal, that common craving across addictions

For individuals using GLP-1 medications to manage weight loss, strength training helps maintain functional strength, preventing the loss of muscle that often accompanies aging or extended periods of inactivity

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Informing the patient about this potential side effect helps manage their expectations and promotes early identification of any complications or adverse reactions

Unfortunately, our database did not include information regarding treatment duration, distribution of time from index date to treatment initiation, the percentage of covered time or whether both medications were taken concurrently in patients receiving combination therapy

The SURPASS trials are designed to evaluate once-weekly tirzepatide doses of 5 mg, 10 mg, and 15 mg with a dose escalation algorithm: starting dose at 2.5 mg weekly for the first 4 weeks, then dose increment of 2.5 mg every 4 weeks until the maintenance dose of 5 mg, 10 mg, or 15 mg is achieved