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Although there is a consensus that increased energy intake, coupled with reduced energy expenditure, is the primary impetus for weight gain, lifestyle interventions aimed at reducing food intake and increasing exercise are largely ineffective in treating obesity (Grill, 2020)

doi: 10.1016/J.CONB.2022.102550

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The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism

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FGF21 is a newly discovered metabolic hormone produced in multiple tissues and secreted in the fasting state and regulates metabolic responses in the pancreas, liver and adipose tissues (95)