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However, it is consistent with other studies, so it warrants further study to better understand the biological mechanisms. Public health implications The researchers acknowledged study limitations, including the potential for confounding in observational studies and the fact that several cancer types in the analysis had low event rates, leading to wide confidence intervals and limiting statistical power

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Metformin and the gut microbiome The gut microbiome and the metagenome (the microbial genome) are areas receiving increasing research attention, and are now considered as environmental factors that contribute to the development of many diseases, including obesity, the metabolic syndrome and type 2 diabetes [7884]

Relevant studies have found that in sarcopenia, the expression of mitochondrial fusion proteins (such as MFN1/2 and OPA1) decreases, while the expression of mitochondrial fission proteins (such as DRP1) relatively increases

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