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10.1016/j.jamcollsurg.2019.04.014 6 CaiX.SheM.XuM.ChenH.LiJ.ChenX.et al (2018)

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Additionally, semaglutide slows the entire digestive process, which may contribute to some of the gastrointestinal side effects, such as nausea, diarrhea, or constipation, that some patients experience
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Structural studies conducted via NMR further demonstrate that the insertion of a single histidine residue at each end of short bioactive peptides promotes a more compact and predictable folding pattern, without significantly altering the peptide backbone

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