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We interpreted these results as a decrease in the pro-inflammatory state of EAT, a known risk factor for CV diseases, which justified the observed improvement in coronary flow reserve (CFR) [10]

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High performance liquid chromatography (HPLC) Samples were analyzed on an HPLC system with a Vanquish Diode Array Detector (Thermo Fischer) connected to a Bio SEC-3 column (300 , 3 m, 4.6 300 mm, Agilent) at 0.3 mL/min, using base buffer as the mobile phase