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Invest 107 , 711 (2001)

It has also been suggested that hepatic hypoinsulinemia may reduce insulin-like growth factor 1 (IGF-1) levels, which may contribute to IR as well by increasing growth hormone and IGF binding globulins (29)

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Non-surgical interventions include injectable treatments such as dermal fillers, biostimulatory fillers, and autologous fat grafting (lipofilling), as well as energy-based devices like radiofrequency (RF), high-intensity focused ultrasound (HIFU), and fractional lasers