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Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis

A 2024 EMA report found that: Only 35% of MAAs in 2023 were submitted to the agency on time (in accordance with the date shown on the applicants letter of intent) When seeking marketing authorisations, 42% of companies asked for more time (or extended clock stops) to respond to questions from the EMAs scientific committees, as their data were not sufficiently mature when filed The average duration of clock stops for initial MAAs in 2023 (198 days) was comparable to the average time for assessment (204 days) In terms of the broader environment for new drug assessment and approval, a comprehensive overhaul of EU pharmaceutical legislation remains in play

Sermorelin: the shortest fully active GHRH fragment Sermorelin takes the opposite design route

Maintaining muscle mass, preventing dehydration, and ensuring adequate nutrition are all important factors when evaluating whether a GLP-1 medication is the right choice

A study may report side effects such as nausea, vomiting, diarrhea, constipation, appetite changes, or other events seen with incretin-based medicines

Innovations such as prolonged-release formulations and once-weekly dosing regimens have emerged, which improve patient compliance and therapeutic outcomes