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A unique side effect seen with Retatrutide 50mg but not with GLP-1 only medications is dysesthesia (a mild tingling or numbness sensation), which is believed to be related to glucagon receptor activation

[DOI] [PubMed] [Google Scholar] 31.Passaro A., Brahmer J., Antonia S., Mok T., Peters S

Patients typically start with a low dose that is gradually increased every four weeks to allow the body to adjust and minimize potential side effects

Interestingly, metabolic disorders such as obesity and type 2 diabetes substantially increase dementia risk, suggesting that metabolic signals may modulate neuroinflammatory processes 5

"We hope that our trial will encourage the industry to conduct a regulatory approval trial so that this drug could be available as an adjunct to insulin therapy to optimize Type 1 diabetes management," Shah said

All of these are once-weekly injectable drugs that are approved by the FDA