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Whilst thirst is not specifically listed as an adverse reaction in the Summary of Product Characteristics (SmPC), dehydration is recognised as a potential adverse effect, primarily related to gastrointestinal side effects

(30, 31) However, they also highlight potential cardiovascular and renal risks, emphasizing the need for careful perioperative monitoring and patient selection

Obese mice that were treated with the gene therapy, which Fractyl calls Rejuva, lost about 20% of their body weight within three weeks

This approach requires careful monitoring but may reduce long-term medication exposure

Many cities in the state arent that walkable, leaving many residents with few options for basic exercise