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In Favor of Antagonism GIP is an intestinally derived, insulinotropic hormone commonly referred to as an incretin (for a comprehensive review see [7])

Please note that this is not medical advice

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Preliminary results from the SURPASS-J-mono study in Japanese patients with T2D who were either therapy nave or on an antidiabetic monotherapy showed a head-to-head comparison of a tirzepatide treatment compared to therapy with the GLP-1RA dulaglutide at a dose of 0.75 mg (54, 76)

The point here is simply that the receptor offers more than one signaling lever to pull

Improved insulin sensitivity may reduce hepatic lipogenesis and visceral fat accumulation