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GLP-1RA and Renal Function With regard to the effects of GLP-1RAs effects on kidney function, CKD is described as one of the HFpEF phenotypes, emphasising significance of understanding the interplay between cardiac and renal function

While SGLT2i primarily reduce preload and afterload through natriuresis and osmotic diuresis, GLP-1 RAs exert anti-inflammatory and metabolic remodeling effects, together potentially providing synergistic cardiovascular protection

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Despite having minimal effects on body weight, treatment with -MSTN/-ActA alone also showed beneficial shifts in the lean/fat body composition in obese mice as previously shown in non-obese mice, NHPs, and humans (Fig