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Month 12 Appetite Reduction Begins Most patients notice reduced hunger and smaller portions within the first few weeks

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When combined with the appetite suppression and insulin secretion effects of GLP-1 receptor activation, the result is a compound that works on weight through multiple complementary pathways simultaneously reduced caloric intake from the GLP-1 side, increased energy expenditure from the glucagon side

GLP-1 and energy balance: An integrated model of short-term and long-term control