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For weight management medications (Wegovy, Saxenda, Zepbound), the FDA-approved labeling recommends discontinuation if suicidal thoughts or behaviors occur

It allows pharmacists to remove inactive ingredients like dyes, lactose, or glutens that can be allergens for some patients, or can allow them to create special flavored medications for children or pets

The culmination came with Wegovys June 4, 2021, approval of semaglutide 2.4 mg specifically for chronic weight management

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In fact, its probably the biggest barrier to increasing use of this medication. For physicians, another large challenge when prescribing GLP-1RA medications includes lack of clinical guidelines for offlabel prescribing