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Those experiences can be genuine, yet a review still cannot tell you whether the patch caused the change or whether the person quietly changed their habits at the same time

This effect can be further compounded by the rate and degree of weight loss, dramatically impacting metabolic rates

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How to Switch When Starting a New Drug If youre moving from injectable tirzepatide (Zepbound) to the semaglutide pill or orforglipron, the equivalent dose is even less clear because not only are you switching drug forms, youre taking an entirely new drug

Lancet Diabetes Endocrinol 7(7):528539 Pratley R, et al (2019) Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial