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Methods: A total of 36 C57BL/6JC mice were randomly divided into a normal-chow diet group (NCD, n = 12), high-fat diet (HFD, n = 12), and HFD+semaglutide group (Sema, n = 12)

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Possible Side Effects Very Common Side Effects Nausea Diarrhea Vomiting Constipation Abdominal pain Hypoglycemia (when used with insulin or sulfonylureas) Common Side Effects Reduced appetite Dizziness Fatigue Injection site reactions Acid reflux Increased heart rate Mild hypersensitivity reactions Rare but Serious Effects Acute pancreatitis Severe allergic reactions (anaphylaxis, angioedema) Gallbladder problems (cholelithiasis, cholecystitis) Seek immediate medical attention if severe symptoms occur