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However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254

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Compounding refers to the process in which a licensed pharmacist, physician, or an individual working under a pharmacist's supervision in an approved facility prepares a customized medication by combining, mixing, or modifying ingredients to meet a specific patient's needs