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Lilly's next-gen Triple G (GLP-1/GIP/glucagon) agonist (Phase 1b, Phase 2): started recruiting for a Phase 3 trial this year approvals are expected by 2026

A person who has gone from 220 pounds to 190 burns meaningfully fewer calories at rest

These include decreased urination or dark-colored urine, dizziness or lightheadedness, extreme thirst and dry mouth, or unusual tiredness and weakness

It is not yet FDA-approved but represents the next frontier in obesity medicine

PC2 (gene: Pcsk2 ) cleaves proglucagon to glucagon, and PC1/3 (gene: Pcsk1 ) cleaves proglucagon to GLP-1 ( The ability of alpha-cells to switch to GLP-1 as their main endocrine output represents an enormous therapeutic opportunity to manage diabetes