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Postgraduate Medicine , 134 (1), 1419
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Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
Dose escalation occurs in fixed increments over multiple weekssemaglutide increases 0.25 mg weekly, tirzepatide 2.5 mg weeklyallowing metabolic adaptation and side-effect assessment before advancing
Guidance for lasting weight loss success
The population who takes these medications have comorbidities or underlying conditions that may influence their response to drugs, Pepin added
