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But the pharmacological effect is the same

Thats led to another trend that worries health care providers: the growing number of people accessing lower-cost GLP-1s through online compounding pharmacies

This led to FDA approval of high dose semaglutide for weight loss in 2021

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GLP-1 Receptor Agonists and Related Mental Health Issues

News-Medical+3EurekAlert!+3ASMBS+3 To put numbers on it: Surgical patients lost ~58 lbs in two years ( 24% of total body weight, or TBW) GLP-1 patients lost only ~12 lbs ( 4.7% TBW) over the same period EurekAlert!+2News-Medical+2 Even among GLP-1 users who continued therapy for a full year, weight loss averaged only ~7% TBWstill far less than surgical outcomes EurekAlert!+2ASMBS+2 Another rigorous analysis published in JAMA Surgery compared weight loss surgery and GLP-1 receptor agonists over two years