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Because the drug activates the same receptors your body uses to signal fullness, the nausea is your medication working, and your body learns to tolerate it over time

2024;64(1):204211e4

Add-on Combination Therapy with Glimepiride, with or without Metformin A total of 441 patients with type 2 diabetes participated in a 24-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of JANUVIA in combination with glimepiride, with or without metformin

doi: 10.1007/s00018-011-0883-3

However, evidence about their effects on cancer risk remains limited

Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)