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Andres Acosta, an obesity expert at Mayo Clinic who was not involved in the study, said that not one, but many genetic variants contribute to the differences in how people respond to these drugs

3,507 GLP-1RAs reduce liver fat accumulation by activating AMPK, which inhibits fatty acid synthesis enzymes and promotes fatty acid -oxidation, thus diminishing lipid droplet accumulation in hepatocytes

GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, which is generally beneficial

Primary Handling Editors: Ashley Castellanos-Jankiewicz, Liam Messin and Sonia Muliyil, in collaboration with the Nature Medicine team

[(accessed on 15 November 2025)];2024 Available online: 70.Novo Nordisk Inc Rybelsus (Semaglutide) Injection for Subcutaneous Use, U.S

The 2 mg pen uses approximately 5.36 mg/mL
