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However, the majority of individuals now receiving GLP-1 medications are using them for obesity management and do not have diabetes

Moreover, key inclusion criteria were as follows: (1) age 50 years and established CVD (e.g

Importantly, lean MASLD patients can progress to fibrosis and cirrhosis at rates similar to their overweight counterparts, underscoring the need for early identification and intervention

Recent animal and human studies highlight the critical role of systemic inflammationdriven by comorbidities such as obesity, T2DM, hypertension, and ageingin the pathogenesis of HFpEF, with obesity recognized as a key driver of this proinflammatory state [156]

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