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Published studies with use of insulin glargine products during pregnancy have not reported a clear association with insulin glargine products and adverse developmental outcomes (see Data)

Specifically, the FDA has approved semaglutide for adults who are clinically obese (BMI of 30 or higher) or overweight (BMI of 27 or higher) when accompanied by at least one weight-related health condition, such as hypertension, hyperlipidemia, cardiovascular disease, prediabetes, or obstructive sleep apnea

The safety profile of semaglutide was comparable to other GLP-1RA [77]

moreover, significant weight loss reduces the requirement for procedures, such as coronary artery bypass grafting, carotid endarterectomy, and percutaneous coronary intervention, as well as peripheral vascular disease, and total mortality by up to 24% [89, 90]

Others see slower changes

Will they experience nausea