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They work around it by improving insulin sensitivity while active, but the underlying cellular resistance often remains

[DOI] [PubMed] [Google Scholar] 827.Perry T., Greig N.H

Additionally, Semaglutide GLP-1 regulates blood sugar levels and improves insulin sensitivity, which is especially beneficial for people with type 2 diabetes or prediabetes

10.3389/fnbeh.2020.614884 [DOI] [PMC free article] [PubMed] 35.Pi-Sunyer X et al (2015) A randomized, controlled trial of 3.0 mg of liraglutide in weight management

We do have to be careful about excess body weight loss, which we know sarcopenia, bone health, and so forth but we really haven't seen any other signals to date, and we're going to continue and look for those