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However, many peptides work locally, never reach the blood stream, and would never be called hormones

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10.1016/J.PHARMTHERA.2020.107503 64 SkorupaA.CiszekM.ChmielikE.Boguszewicz.Oczko-WojciechowskaM.KowalskaM.et al (2021)

One such substance, LY3437943, has been discovered to exhibit strong agonist activity on three distinct receptors, including the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors