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Trial Design and Patient Population Investigators conducted a double-blind, active-comparator-controlled, noninferiority trial

[1] [5] Whilst weight loss is generally beneficial for metabolic health, changes in body mass can alter biomechanics and place different stresses on joints and supporting musculature

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Most patients notice reduced hunger within the first 12 weeks of treatment, though the effect intensifies over 48 weeks as the dose increases and your body adjusts

Patients who have refractory disease, especially those with a specific brain lesion, should be considered for surgery