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In older adults, the preservation of functional capacity and independence, as well as the prevention of frailty and sarcopenia, depends critically on maintaining adequate muscle (especially skeletal) mass and quality

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[46] Senescent cells secrete a harmful mix of inflammatory molecules known as the senescence-associated secretory phenotype (SASP)

GLP-1 medications a class of drugs originally developed to treat diabetes and now used for weight management and longevity help regulate appetite, gastric emptying, and post-meal glucose

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Abbreviations AE: Adverse event AgRP: Agouti-related peptide ALAT: Alanine aminotransferase Anti-CGRP mAbs: Monoclonal antibodies against calcitonin gene-related peptide AP: Area postrema BMI: Body mass index CART: Cocaine- and amphetamine-regulated transcript CGRP: Calcitonin gene-related peptide CSF: Cerebrospinal fluid ENS: Enteric nervous system FUP: Follow-up GCL: Ganglion cell layer GLP-1: Glucagon-like peptide-1 GLP-1-RA: Glucagon-like peptide-1 receptor agonist Hyp: Hypothalamus ICP: Intracranial pressure IIH: Idiopathic intracranial hypertension IIH-WOP: Idiopathic intracranial hypertension without papilledema MHD: Monthly headache days NPY: Neuropeptide Y NTS: Nucleus tractus solitarii OCT: Optical coherence tomography ONSD: Optic nerve sheath diameter POMS: Proopiomelanocortin pRNFL: Peripapillary retinal nerve fiber layer pwIIH: Patients with idiopathic intracranial hypertension SFO: Subfornical organ UCWM: Usual care weight management ULN: Upper limit of normal VIIH: Vienna Idiopathic Intracranial Hypertension References Mollan SP et al (2018) Idiopathic intracranial hypertension: consensus guidelines on management