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Abbreviations 4-PBA: 4-Phenylbutyric acid AGEs: Advanced glycation end-products Akt: Protein kinase B AMPK: Adenosine monophosphate-activated protein kinase ATF4: Activating transcription factor 4 ATG: Autophagy-related ATP: Adenosine triphosphate BCL-2: B-cell lymphoma-2 CaMKK: Calmodulin-dependent protein kinase kinase cAMP: Cyclic adenosine monophosphate Drp1: Dynamin-related protein 1 eIF2: Eukaryotic translation initiation factor 2 eNOS: Endothelial nitric oxide synthase ER: Endoplasmic reticulum ERS: Endoplasmic reticulum stress Fis1: Fission-1 protein GLP-1: Glucagon-like peptide-1 GLP-1R: GLP-1 receptor HUVECs: Human umbilical vein endothelial cells LC3: Light chain 3 LDL: Low-density lipoprotein MCP-1: Monocyte chemoattractant protein-1 mTOR: Mammalian targets of rapamycin mtROS: Mitochondrial reactive oxygen species NADPH: Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor-B NO: Nitric oxide PERK: PKR-like ER-resident kinase PI3K: Phosphoinositide 3-kinase PINK1: Phosphatase and tensin homolog-induced putative kinase 1 PKC: Protein kinase C ROS: Reactive oxygen species RPE: Retinal pigment epithelial Wnt: Wingless/integrated References Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al

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Future studies should thus consider atypical scores and baseline inflammatory markers for pre-stratified designs

These drugs are not standalone solutions but work best when paired with a healthy diet and regular exercise, he advises

doi: 10.1001/jamainternmed.2025.6112